Industry Resources
Valuable information on oligonucleotides production and chemical manufacturing
Leading Organizations and Websites
We've compiled a list of the most valuable resources in the field of oligonucleotide production and chemical manufacturing. These authoritative sources provide essential information for researchers, manufacturers, and industry professionals.
The Oligonucleotide Therapeutics Society (OTS)
The premier society dedicated to the advancement of oligonucleotide therapeutics. Provides educational resources, conference information, and the latest research in the field.
Key Features: Annual conferences, scientific publications, educational resources
Visit Website →American Chemical Society (ACS) - Division of Medicinal Chemistry
The ACS Division of Medicinal Chemistry provides valuable resources on chemical synthesis, including techniques relevant to oligonucleotide production.
Key Features: Scientific journals, continuing education, technical presentations
Visit Website →Journal of Nucleic Acids
An open-access journal publishing research articles in all areas of nucleic acids, including oligonucleotide synthesis, modifications, and applications.
Key Features: Peer-reviewed research, special issues on synthesis technologies
Visit Website →Nucleic Acids Research (NAR)
One of the leading journals in molecular biology focusing on nucleic acids research, including oligonucleotide synthesis and applications.
Key Features: High-impact research papers, methodological advances, databases
Visit Website →International Society for Pharmaceutical Engineering (ISPE)
Provides resources on GMP compliance and manufacturing best practices applicable to oligonucleotide production facilities.
Key Features: Industry standards, regulatory guidance, manufacturing best practices
Visit Website →Drug, Chemical & Associated Technologies Association (DCAT)
Industry association providing insights on pharmaceutical chemical manufacturing, supply chain, and market trends.
Key Features: Market intelligence, networking opportunities, industry news
Visit Website →Tides: Oligonucleotide and Peptide Therapeutics
Annual conference focused on oligonucleotide and peptide therapeutics, providing the latest advances in the field.
Key Features: Industry conference, technical presentations, networking
Visit Website →FDA Guidance Documents for Oligonucleotide Products
Regulatory guidance for the development and manufacturing of oligonucleotide-based therapeutic products.
Key Features: Regulatory requirements, quality standards, approval pathways
Visit Website →Educational Materials
Introduction to Oligonucleotide Synthesis
A comprehensive guide to the fundamental principles and methods of oligonucleotide synthesis.
Read More →Quality Control in Oligonucleotide Manufacturing
Learn about the essential quality control procedures for ensuring high-purity oligonucleotide products.
Read More →Advances in Oligonucleotide Synthesis
Explore recent technological advances in the field of oligonucleotide synthesis and production.
Read More →Regulatory Considerations for Oligonucleotide Products
Navigate the complex regulatory landscape for oligonucleotide-based products and therapeutics.
Read More →Frequently Asked Questions
What are oligonucleotides?
Oligonucleotides are short DNA or RNA molecules, typically with 20 or fewer bases, used in genetic testing, research, and as therapeutic agents. They can be synthesized chemically and often include modifications to enhance their properties for specific applications.
What are the main applications of synthetic oligonucleotides?
Synthetic oligonucleotides have numerous applications, including PCR primers and probes, antisense therapies, CRISPR guide RNAs, aptamers, diagnostic tools, and research reagents for studying gene function and regulation.
What is the difference between DNA and RNA oligonucleotides?
DNA oligonucleotides contain deoxyribose sugar and the bases A, G, C, and T. RNA oligonucleotides contain ribose sugar (with an additional hydroxyl group) and the bases A, G, C, and U (instead of T). RNA oligonucleotides are generally more susceptible to degradation than DNA oligonucleotides.
What are modified oligonucleotides?
Modified oligonucleotides contain chemical alterations to the standard nucleotide structure, such as phosphorothioate backbones, 2'-O-methyl groups, or locked nucleic acids (LNAs). These modifications can enhance stability, binding affinity, or other properties for specific applications.
What quality parameters are important for oligonucleotides?
Key quality parameters include sequence accuracy, chemical purity (absence of truncated sequences and other impurities), integrity (lack of degradation), sterility (for therapeutic applications), and accurate concentration determination.
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